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WTH Is Cerebrolysin, Actually?
Some claim it's a panacea for brain diseases, but does this pig brain concoction live up to the hype?
The BBB limits the brain penetration of most CNS drug candidates.... Radiolabeled histamine, a small molecule of just 111 Da, was injected intravenously into an adult mouse, and the animal was killed 30 mins later for whole-body autoradiography [1]. Essentially, 100% of large-molecule pharmaceutics, including peptides, recombinant proteins, monoclonal antibodies, RNA interference (RNAi)-based drugs and gene therapies, do not cross the BBB. The replication crisis and work of Ionnidis and other metascientists leads us to believe that most scientific research is false, especially in biomedicine, and especially in lower-tier biomedical journals, where all the primary source papers on Cerebrolysin appear.
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