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Zebrafish protein unlocks dormant genes for heart repair

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish.

The OUTREACH consortium is a collaboration between research institutes and all academic hospitals involved in treating patients with congenital heart defects in the Netherlands. Publication Cross-Species Comparison Reveals Hmga1 Reduces H3K27me3 Levels to Promote Cardiomyocyte Proliferation and Cardiac Regeneration. Mara Bouwman, Dennis E.M. de Bakker, Hessel Honkoop, Alexandra E. Giovou, Danielle Versteeg, Arie R. Boender, Phong D. Nguyen, Merel Slotboom, Daniel Colquhoun, Marta Vigil-Garcia, Lieneke Kooijman, Rob Janssen, Ingeborg B. Hooijkaas, Marie Günthel, Kimberly J. Visser, Mischa Klerk, Lorena Zentilin, Mauro Giacca, Jan Kaslin, Gerard J.J. Boink, Eva van Rooij, Vincent M. Christoffels, Jeroen Bakkers.

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